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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC1
All Species:
22.73
Human Site:
S575
Identified Species:
62.5
UniProt:
Q92574
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92574
NP_000359.1
1164
129767
S575
G
D
R
E
C
Q
T
S
L
E
T
S
I
F
T
Chimpanzee
Pan troglodytes
XP_520334
1163
129674
S574
G
D
R
E
C
Q
T
S
L
E
T
S
I
F
T
Rhesus Macaque
Macaca mulatta
XP_001103589
1163
129467
S574
G
D
R
E
C
Q
T
S
L
E
T
S
I
L
T
Dog
Lupus familis
XP_537808
1169
129668
S575
G
D
R
E
R
Q
T
S
L
E
T
N
I
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9EP53
1161
128727
S572
G
D
R
D
R
Q
T
S
L
E
T
S
I
L
T
Rat
Rattus norvegicus
Q9Z136
1163
129004
S575
G
D
R
D
R
Q
T
S
L
E
T
S
I
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415449
1156
128927
S578
A
G
N
R
E
G
T
S
G
E
T
S
I
L
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001119992
1001
113305
I496
Q
E
D
Q
E
H
S
I
V
Q
V
L
E
I
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190249
1454
159903
Q642
P
K
Y
D
V
E
K
Q
S
G
Q
V
V
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.1
89.3
N.A.
87.2
86.4
N.A.
N.A.
76.3
N.A.
N.A.
N.A.
N.A.
23.5
N.A.
25.9
Protein Similarity:
100
99.6
98.7
93.5
N.A.
92
91.4
N.A.
N.A.
84.7
N.A.
N.A.
N.A.
N.A.
43.2
N.A.
43.3
P-Site Identity:
100
100
93.3
80
N.A.
80
80
N.A.
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
93.3
86.6
N.A.
86.6
86.6
N.A.
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
34
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
67
12
34
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
12
0
45
23
12
0
0
0
78
0
0
12
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
23
0
% F
% Gly:
67
12
0
0
0
12
0
0
12
12
0
0
0
0
12
% G
% His:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
12
0
0
0
0
78
12
0
% I
% Lys:
0
12
0
0
0
0
12
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
67
0
0
12
0
56
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
12
0
0
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
0
0
12
0
67
0
12
0
12
12
0
0
0
0
% Q
% Arg:
0
0
67
12
34
0
0
0
0
0
0
0
0
12
0
% R
% Ser:
0
0
0
0
0
0
12
78
12
0
0
67
0
0
0
% S
% Thr:
0
0
0
0
0
0
78
0
0
0
78
0
0
0
78
% T
% Val:
0
0
0
0
12
0
0
0
12
0
12
12
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _